description diseaseOntologyId link name A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS. DOID:635 http://purl.obolibrary.org/obo/DOID_635 acquired immunodeficiency syndrome An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection. DOID:639 http://purl.obolibrary.org/obo/DOID_639 acute disseminated encephalomyelitis Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition. C3353 http://purl.obolibrary.org/obo/NCIT_C3353 Acute Respiratory Distress Syndrome An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands. DOID:13774 http://purl.obolibrary.org/obo/DOID_13774 Addison's disease The process of change in the structure and function of an organism that occurs with the passage of time. NCIT:C16269 http://purl.obolibrary.org/obo/NCIT_C16269 Aging A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol. (UMLS CUI:C0001973) DOID:0050741 http://purl.obolibrary.org/obo/DOID_0050741 alcohol dependence A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. DOID:1574 http://purl.obolibrary.org/obo/DOID_1574 alcohol use disorder An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods. DOID:1205 http://purl.obolibrary.org/obo/DOID_1205 allergic hypersensitivity disease A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites. DOID:4481 http://purl.obolibrary.org/obo/DOID_4481 allergic rhinitis An autoimmune disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots. DOID:986 http://purl.obolibrary.org/obo/DOID_986 alopecia areata A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. DOID:10652 http://purl.obolibrary.org/obo/DOID_10652 Alzheimer's disease A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells. DOID:2355 http://purl.obolibrary.org/obo/DOID_2355 anemia Paroxysms of chest pain due to reduced oxygen to the heart. (UMLS CUI:C0002962) NCIT:C51221 http://purl.obolibrary.org/obo/NCIT_C51221 Angina A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath. DOID:7427 http://purl.obolibrary.org/obo/DOID_7427 anthrax disease An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin). DOID:2988 http://purl.obolibrary.org/obo/DOID_2988 antiphospholipid syndrome An autoimmune disease that is characterized by myositis, arthralgia, Raynaud phenomenon, mechanic hands, interstitial lung disease, and serum autoantibodies to aminoacyl transfer RNA synthetases. DOID:0080744 http://purl.obolibrary.org/obo/DOID_0080744 antisynthetase syndrome A cognitive disorder that involves an excessive, irrational dread of everyday situations. DOID:2030 http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder Arrhythmia is a cardiovascular system symptom consisting of an alteration in rhythm of the heartbeat either in time or force. SYMP:0000287 http://purl.obolibrary.org/obo/SYMP_0000287 arrhythmia A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough. (UMLS CUI:C0032290) DOID:0050152 http://purl.obolibrary.org/obo/DOID_0050152 aspiration pneumonia A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. DOID:2841 http://purl.obolibrary.org/obo/DOID_2841 asthma An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking. DOID:3310 http://purl.obolibrary.org/obo/DOID_3310 atopic dermatitis A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain. (UMLS CUI:C0004238) DOID:0060224 http://purl.obolibrary.org/obo/DOID_0060224 atrial fibrillation An autoimmune disease of cardiovascular system that is characterized by deterioration of the function of the heart muscle. DOID:0040095 http://purl.obolibrary.org/obo/DOID_0040095 autoimmune cardiomyopathy An autoimmune hepatitis that is characterized by primary biliary cirrhosis clinical, biochemical, and histologic characteristics with antinuclear antibody positive sera. DOID:0080742 http://purl.obolibrary.org/obo/DOID_0080742 autoimmune cholangitis An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues. DOID:417 http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system. DOID:0060005 http://purl.obolibrary.org/obo/DOID_0060005 autoimmune disease of endocrine system An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system. DOID:0060032 http://purl.obolibrary.org/obo/DOID_0060032 autoimmune disease of musculoskeletal system An autoimmune disease of urogenital tract that is located_in the renal glomerulus. DOID:0040094 http://purl.obolibrary.org/obo/DOID_0040094 autoimmune glomerulonephritis An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies. DOID:718 http://purl.obolibrary.org/obo/DOID_718 autoimmune hemolytic anemia An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells. DOID:2048 http://purl.obolibrary.org/obo/DOID_2048 autoimmune hepatitis An autoimmune disease of peripheral nervous system that results in peripheral neuropathy. DOID:0040087 http://purl.obolibrary.org/obo/DOID_0040087 autoimmune peripheral neuropathy A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies. DOID:8924 http://purl.obolibrary.org/obo/DOID_8924 autoimmune thrombocytopenic purpura An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress. DOID:4492 http://purl.obolibrary.org/obo/DOID_4492 avian influenza Surgery performed in morbidly obese patients to help promote weight loss. The procedure aims at the reduction of the stomach size and it is usually achieved either with the implantation of a medical device or the removal of part of the stomach. NCIT:C84399 http://purl.obolibrary.org/obo/NCIT_C84399 Bariatric Surgery Bilateral pleural effusion (disorder) (UMLS CUI:C0747635) SNOMEDCT:425802001 http://purl.bioontology.org/ontology/SNOMEDCT/425802001 Bilateral pleural effusion (disorder) A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder. DOID:13608 http://purl.obolibrary.org/obo/DOID_13608 biliary atresia A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. DOID:1247 http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease The injection of whole blood or a blood component directly into the bloodstream. NCIT:C15192 http://purl.obolibrary.org/obo/NCIT_C15192 Blood Transfusion A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage. DOID:0080006 http://purl.obolibrary.org/obo/DOID_0080006 bone development disease A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. DOID:0080001 http://purl.obolibrary.org/obo/DOID_0080001 bone disease A brain glioma that has_material_basis_in abnormally proliferating cells derives_from glial cells, has_symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems. DOID:3073 http://purl.obolibrary.org/obo/DOID_3073 brain glioblastoma multiforme A brain cancer that has_material_basis_in glial cells. DOID:0060108 http://purl.obolibrary.org/obo/DOID_0060108 brain glioma A thoracic cancer that originates in the mammary gland. DOID:1612 http://purl.obolibrary.org/obo/DOID_1612 breast cancer A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. (UMLS CUI:C0006267) DOID:9563 http://purl.obolibrary.org/obo/DOID_9563 bronchiectasis A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen. DOID:2942 http://purl.obolibrary.org/obo/DOID_2942 bronchiolitis A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness. DOID:6132 http://purl.obolibrary.org/obo/DOID_6132 bronchitis Chronic lung disease requiring treatment with oxygen for at least 28 days and with a spectrum of severity from mild to severe, that predominantly affects premature infants. While the radiologic pattern is typical in the closer to term patient, the pattern in the small preterm infant is very non-discrete and variable. NCIT:C90599 http://purl.obolibrary.org/obo/NCIT_C90599 Bronchopulmonary Dysplasia A dermatitis that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested. DOID:8502 http://purl.obolibrary.org/obo/DOID_8502 bullous skin disease A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. DOID:162 http://purl.obolibrary.org/obo/DOID_162 cancer A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all. DOID:0060319 http://purl.obolibrary.org/obo/DOID_0060319 cardiac arrest A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. DOID:0050700 http://purl.obolibrary.org/obo/DOID_0050700 cardiomyopathy A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. DOID:1287 http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. DOID:10608 http://purl.obolibrary.org/obo/DOID_10608 celiac disease A subperiosteal hemorrhage limited to the surface of one cranial bone, a usually benign condition seen in the newborn as a result of bone trauma. NCIT:C50484 http://purl.obolibrary.org/obo/NCIT_C50484 Cephalohematoma A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance. DOID:1969 http://purl.obolibrary.org/obo/DOID_1969 cerebral palsy An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. DOID:6713 http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters. DOID:8659 http://purl.obolibrary.org/obo/DOID_8659 chickenpox A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash. DOID:0050012 http://purl.obolibrary.org/obo/DOID_0050012 chikungunya childhood type dermatomyositis DOID:14203 http://purl.obolibrary.org/obo/DOID_14203 childhood type dermatomyositis choledochal cyst DOID:899 http://purl.obolibrary.org/obo/DOID_899 choledochal cyst A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock. DOID:1498 http://purl.obolibrary.org/obo/DOID_1498 cholera A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection. DOID:0050697 http://purl.obolibrary.org/obo/DOID_0050697 chorioamnionitis A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes. DOID:0080014 http://purl.obolibrary.org/obo/DOID_0080014 chromosomal disease A disease course that (a) does not terminate in a return to normal homeostasis and (b) would, absent intervention, fall within abnormal homeostatic range. OGMS:0000064 http://purl.obolibrary.org/obo/OGMS_0000064 chronic disease course A kidney failure that is characterized by the gradual loss of kidney function. (UMLS CUI:C1561643) DOID:784 http://purl.obolibrary.org/obo/DOID_784 chronic kidney disease Hepatic necrosis, inflammation, or scarring due to any cause that persists for more than 6 months. Manifestations may include signs and symptoms of cholestasis, portal hypertension, and/or abnormal liver function tests. (UMLS CUI:C0341439) NCIT:C113609 http://purl.obolibrary.org/obo/NCIT_C113609 Chronic Liver Disease An obstructive lung disease that is characterized by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease. DOID:3083 http://purl.obolibrary.org/obo/DOID_3083 chronic obstructive pulmonary disease Chronic plaque psoriasis is the most common presentation of psoriasis. It presents as small to large, well-demarcated, red, scaly and thickened areas of skin. It most likely to affect elbows, knees, and lower back but may arise on any part of the body. N/A https://dermnetnz.org/topics/chronic-plaque-psoriasis/ chronic plaque psoriasis Inflammation of the paranasal sinuses that typically lasts beyond eight weeks. It is caused by infections, allergies, and the presence of sinus polyps or deviated septum. Signs and symptoms include headache, nasal discharge, swelling in the face, dizziness, and breathing difficulties. (UMLS CUI:C0149516) NCIT:C35151 http://purl.obolibrary.org/obo/NCIT_C35151 Chronic Sinusitis A chronic urticaria that is characterized by urticaria independent of any exogenous stimulus. DOID:0080749 http://purl.obolibrary.org/obo/DOID_0080749 chronic spontaneous urticaria liver cirrhosis DOID:5082 http://purl.obolibrary.org/obo/DOID_5082 cirrhosis Clinically isolated syndrome (CIS) is one of the MS disease courses. CIS refers to a first episode of neurologic symptoms that lasts at least 24 hours and is caused by inflammation or demyelination (loss of the myelin that covers the nerve cells) in the central nervous system (CNS). N/A https://www.nationalmssociety.org/Symptoms-Diagnosis/Clinically-Isolated-Syndrome-(CIS) clinically isolated syndrome A colitis characterized by an overgrowth of Clostridium difficile bacteria. DOID:0060185 http://purl.obolibrary.org/obo/DOID_0060185 Clostridium difficile colitis An inflammatory bowel disease that involves inflammation located_in colon. DOID:0060180 http://purl.obolibrary.org/obo/DOID_0060180 colitis A large intestine cancer that is located_in the colon and/or located_in the rectum. DOID:9256 http://purl.obolibrary.org/obo/DOID_9256 colorectal cancer An agammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. DOID:12177 http://purl.obolibrary.org/obo/DOID_12177 common variable immunodeficiency An adrenal gland disease that is characterized by cortisol deficiency, hypoaldosteronism and excessive or insufficient sex hormones, has_material_basis_in the mutation in the gene for 21-hydroxylase, 11beta-hydroxylase, 3beta-hydroxysteroid, 17alpha-hydroxylase or 20,22-desmolase. DOID:0050546 http://purl.obolibrary.org/obo/DOID_0050546 congenital adrenal insufficiency congenital heart disease DOID:1682 http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease A syphilis that results_in a multisystem infection in the fetus via the placenta. DOID:9856 http://purl.obolibrary.org/obo/DOID_9856 congenital syphilis A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. DOID:6000 http://purl.obolibrary.org/obo/DOID_6000 congestive heart failure A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids. DOID:6195 http://purl.obolibrary.org/obo/DOID_6195 conjunctivitis A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage. DOID:65 http://purl.obolibrary.org/obo/DOID_65 connective tissue disease An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. DOID:3393 http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2. DOID:0080600 http://purl.obolibrary.org/obo/DOID_0080600 COVID-19 Acute respiratory distress syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) C171551 http://purl.obolibrary.org/obo/NCIT_C171551 COVID-19-Associated Acute Respiratory Distress Syndrome A neuropathy that is located_in one of the twelve cranial nerves. DOID:5656 http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease http://purl.obolibrary.org/obo/DOID_0081012;https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1 DOID:0081012 critical COVID-19 An intestinal disease that involves inflammation located_in intestine. DOID:8778 http://purl.obolibrary.org/obo/DOID_8778 Crohn's disease A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight. DOID:0050169 http://purl.obolibrary.org/obo/DOID_0050169 cutaneous lupus erythematosus A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs. DOID:1485 http://purl.obolibrary.org/obo/DOID_1485 cystic fibrosis Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid. The cysts vary in size, and they can grow very large. DOID:2975 http://purl.obolibrary.org/obo/DOID_2975 cystic kidney disease A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and that has_material_basis_in mutations in the CTNS gene, located on chromosome 17. DOID:1064 http://purl.obolibrary.org/obo/DOID_1064 cystinosis Acute myeloid leukemia not associated with cytogenetic abnormalities. NCIT:C122687 http://purl.obolibrary.org/obo/NCIT_C122687 Cytogenetically Normal Acute Myeloid Leukemia A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies. NCIT:C53649 http://purl.obolibrary.org/obo/NCIT_C53649 Cytomegaloviral Infection A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. DOID:1307 http://purl.obolibrary.org/obo/DOID_1307 dementia Dementia with psychosis (UMLS CUI:C0543884) UMLS CUI:C0543884 Dementia with psychosis A viral infectious disease that results in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding. DOID:12205 http://purl.obolibrary.org/obo/DOID_12205 dengue disease A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever. DOID:12206 http://purl.obolibrary.org/obo/DOID_12206 dengue hemorrhagic fever Dependence on peritoneal dialysis due to end stage renal disease (UMLS CUI:C1997877) SNOMEDCT:428937001 http://purl.bioontology.org/ontology/SNOMEDCT/428937001 Dependence on peritoneal dialysis due to end stage renal disease A myositis that results_in inflammation located_in muscle or located_in skin where a skin rash is often seen prior to the onset of muscle weakness. The disease may result from either a viral infection or an autoimmune reaction. DOID:10223 http://purl.obolibrary.org/obo/DOID_10223 dermatomyositis A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source. DOID:8913 http://purl.obolibrary.org/obo/DOID_8913 dermatophytosis A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. DOID:0060037 http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. DOID:9351 http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys. DOID:11405 http://purl.obolibrary.org/obo/DOID_11405 diphtheria A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. DOID:4 http://purl.obolibrary.org/obo/DOID_4 disease A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. DOID:0050117 http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease that involving errors in metabolic processes of building or degradation of molecules. DOID:0014667 http://purl.obolibrary.org/obo/DOID_0014667 disease of metabolism An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall. (UMLS CUI:C0012813) DOID:7475 http://purl.obolibrary.org/obo/DOID_7475 diverticulitis A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted by contaminated fomites, or transmitted by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding. DOID:4325 http://purl.obolibrary.org/obo/DOID_4325 Ebola hemorrhagic fever An infection that is caused by Epstein-Barr virus. NCIT:C38759 http://purl.obolibrary.org/obo/NCIT_C38759 EBV Infection A lymphoproliferative disorder that develops following organ transplantation and is associated with Epstein-Barr virus infection. NCIT:C27696 http://purl.obolibrary.org/obo/NCIT_C27696 EBV-Related Post-Transplant Lymphoproliferative Disorder A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes. DOID:9123 http://purl.obolibrary.org/obo/DOID_9123 eczema herpeticum Eczema vaccinatum: A common concern with smallpox vaccination involving the implantation of the vaccinia virus from the vaccination into the skin of a person with eczema (atopic dermatitis), sometimes with a fatal outcome. Disrupted skin permits viral implantation. Once the virus is implanted, it spreads from cell to cell producing extensive lesions. The skin lesions appear identical to a primary smallpox vaccination. Confluent lesions often cover the entire face, the crook of the elbow in the antecubital fossa, and behind the knee in the popliteal fossa. Viremia (viral spread through the bloodstream) may also occur allowing for the spread of virus to other parts of the body, including skin that is not affected by eczema. Bacterial and fungal invas N/A https://www.medicinenet.com/script/main/art.asp?articlekey=21872 eczema vaccinatum A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms. DOID:4377 http://purl.obolibrary.org/obo/DOID_4377 egg allergy A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms. DOID:9588 http://purl.obolibrary.org/obo/DOID_9588 encephalitis A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease. DOID:783 http://purl.obolibrary.org/obo/DOID_783 end stage renal disease A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves. DOID:10314 http://purl.obolibrary.org/obo/DOID_10314 endocarditis An esophagitis characterized by inflammation involving eosinophils located_in esophagus. DOID:13922 http://purl.obolibrary.org/obo/DOID_13922 eosinophilic esophagitis A vesiculobullous skin disease that is characterized by formation of blisters with only minor skin trauma, which can cause widespread wounds, dehydration, electrolyte abnormalities, and severe infection, frequently develops_from mutations in connective tissue elements, including genes encoding keratin, collagen, and laminin. DOID:2730 http://purl.obolibrary.org/obo/DOID_2730 epidermolysis bullosa A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. DOID:1826 http://purl.obolibrary.org/obo/DOID_1826 epilepsy Infection with the organism Escherichia Coli. NCIT:C34594 http://purl.obolibrary.org/obo/NCIT_C34594 Escherichia Coli Infection esophageal atresia DOID:10485 http://purl.obolibrary.org/obo/DOID_10485 esophageal atresia A gastrointestinal system disease that is characterized by abnormal development of the esophagus and trachea where the upper esophagus does not connect (atresia) to the lower esophagus and stomach and may also include tracheoesophageal fistula where the esophagus and the trachea are abnormally connected which allows fluids from the esophagus to get into the airways and interfere with breathing. DOID:0080171 http://purl.obolibrary.org/obo/DOID_0080171 esophageal atresia/tracheoesophageal fistula A clinical finding indicating less than normal growth in an infant or child, or a state of global decline in an adult. (UMLS CUI:C0015544) NCIT:C107587 http://purl.obolibrary.org/obo/NCIT_C107587 Failure to Thrive A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. NCIT:C17726 http://purl.obolibrary.org/obo/NCIT_C17726 Family Medical History fibromyalgia DOID:631 http://purl.obolibrary.org/obo/DOID_631 fibromyalgia Focal segmental glomerulosclerosis (FSGS) is a disease in which scar tissue develops on the parts of the kidneys that filter waste from the blood (glomeruli). FSGS can be caused by a variety of conditions. DOID:1312 http://purl.obolibrary.org/obo/DOID_1312 focal segmental glomerulosclerosis A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system. DOID:3044 http://purl.obolibrary.org/obo/DOID_3044 food allergy gastroesophageal reflux disease DOID:8534 http://purl.obolibrary.org/obo/DOID_8534 gastroesophageal reflux disease A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes. DOID:3068 http://purl.obolibrary.org/obo/DOID_3068 glioblastoma An autoimmune disease that is characterized by antibody attack of the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure. DOID:9808 http://purl.obolibrary.org/obo/DOID_9808 Goodpasture syndrome An autoimmune disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera, and is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels. DOID:12132 http://purl.obolibrary.org/obo/DOID_12132 granulomatosis with polyangiitis An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland. DOID:12361 http://purl.obolibrary.org/obo/DOID_12361 Graves' disease An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system. DOID:12842 http://purl.obolibrary.org/obo/DOID_12842 Guillain-Barre syndrome A bacterial meningitis that has_material_basis_in Haemophilus influenzae infection. DOID:0080179 http://purl.obolibrary.org/obo/DOID_0080179 haemophilus meningitis Having no significant health-related issues. NCIT:C115935 http://purl.obolibrary.org/obo/NCIT_C115935 healthy Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. (UMLS CUI:C0018801) NCIT:C50577 http://purl.obolibrary.org/obo/NCIT_C50577 Heart Failure A surgical procedure in which a damaged heart is removed and replaced by another heart from a suitable donor. NCIT:C15246 http://purl.obolibrary.org/obo/NCIT_C15246 Heart Transplantation A bacterial infection of the stomach, caused by Helicobacter pylori. It is associated with the development of peptic ulcer and mucosa-associated lymphoid tissue lymphoma. NCIT:C39293 http://purl.obolibrary.org/obo/NCIT_C39293 Helicobacter Pylori Infection An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. DOID:2531 http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer A disease of anatomical entity that has_material_basis_in hematopoietic cells. DOID:74 http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease A central nervous system disease that is characterized by the complete paralysis of half of the body. DOID:10969 http://purl.obolibrary.org/obo/DOID_10969 hemiplegia hemoglobinopathy DOID:2860 http://purl.obolibrary.org/obo/DOID_2860 hemoglobinopathy A kidney disease that is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. DOID:12554 http://purl.obolibrary.org/obo/DOID_12554 hemolytic-uremic syndrome (UMLS CUI:C0267797) DOID:2237 http://purl.obolibrary.org/obo/DOID_2237 hepatitis A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:12549 http://purl.obolibrary.org/obo/DOID_12549 hepatitis A A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:2043 http://purl.obolibrary.org/obo/DOID_2043 hepatitis B A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. DOID:1883 http://purl.obolibrary.org/obo/DOID_1883 hepatitis C A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia. DOID:8536 http://purl.obolibrary.org/obo/DOID_8536 herpes zoster A viral infectious disease that has_material_basis_in Human betaherpesvirus 5. DOID:0080827 http://purl.obolibrary.org/obo/DOID_0080827 human cytomegalovirus infection A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands. DOID:526 http://purl.obolibrary.org/obo/DOID_526 human immunodeficiency virus infectious disease hydronephrosis DOID:11111 http://purl.obolibrary.org/obo/DOID_11111 hydronephrosis An artery disease characterized by chronic elevated blood pressure in the arteries. DOID:10763 http://purl.obolibrary.org/obo/DOID_10763 hypertension Hypertension not adequately controlled (UMLS CUI:C0857354) UMLS CUI:C0857354 Hypertension not adequately controlled A glucose metabolism disease that is characterized by abnormally low levels of blood glucose. DOID:9993 http://purl.obolibrary.org/obo/DOID_9993 hypoglycemia Lower than normal levels of sodium in the circulating blood. (UMLS CUI:C0020625) NCIT:C37976 http://purl.obolibrary.org/obo/NCIT_C37976 Hyponatremia A thyroid gland disease which involves an underproduction of thyroid hormone. DOID:1459 http://purl.obolibrary.org/obo/DOID_1459 hypothyroidism A gynecologic surgery history in which a woman has had a hysterectomy. OBI:0002398 http://purl.obolibrary.org/obo/OBI_0002398 hysterectomy history A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed. DOID:1697 http://purl.obolibrary.org/obo/DOID_1697 ichthyosis A pulmonary fibrosis that is characterized by scarring of the lung. DOID:0050156 http://purl.obolibrary.org/obo/DOID_0050156 idiopathic pulmonary fibrosis A loss of any arm of immune functions, resulting in potential or actual increase in infections. This state may be reached secondary to specific genetic lesions, syndromes with unidentified or polygenic causes, acquired deficits from other disease states, or as result of therapy for other diseases or conditions. (UMLS CUI:C2186379) NCIT:C14139 http://purl.obolibrary.org/obo/NCIT_C14139 Immunocompromised An innate tolerance that prevents the body from attacking native proteins and tissue. NCIT:C17712 http://purl.obolibrary.org/obo/NCIT_C17712 Immunologic Tolerance Immunosuppressive Disorder A disorder in which immune function is suppressed. C178942 http://purl.obolibrary.org/obo/NCIT_C178942 Immunosuppressive Disorder An intestinal disease characterized by inflammation located in all parts of digestive tract. DOID:0050589 http://purl.obolibrary.org/obo/DOID_0050589 inflammatory bowel disease An infectious or non infectious disorder characterized by signs and symptoms derived from focal or extensive tissue infiltration by acute (e.g., polymorphonuclear) or chronic (e.g., lymphocytic-plasmacytic) inflammatory cells. Representative examples of infectious disorders include viral infections, bacterial infections, and parasitic infections. Representative examples of non-infectious inflammatory disorders include inflammatory bowel disease and inflammatory polyps C93210 http://purl.obolibrary.org/obo/NCIT_C93210 Inflammatory Disorder A viral infectious disease that results in infection, located in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness. DOID:8469 http://purl.obolibrary.org/obo/DOID_8469 influenza A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough. DOID:3082 http://purl.obolibrary.org/obo/DOID_3082 interstitial lung disease Interstitial nephritis is a kidney disorder. The kidneys filter waste and extra fluid from the body. When you have interstitial nephritis, the spaces between tubules (small tubes) inside the kidney become inflamed. This reduces the kidneys' ability to filter properly. DOID:1063 http://purl.obolibrary.org/obo/DOID_1063 interstitial nephritis An intestinal disease that involves intestinal infection that has_material_basis_in viruses, bacteria, fungi and parasites. DOID:100 http://purl.obolibrary.org/obo/DOID_100 intestinal infectious disease Irritable bowel syndrome with diarrhea (UMLS CUI:C0348898) SNOMEDCT:197125005 http://purl.bioontology.org/ontology/SNOMEDCT/197125005 Irritable bowel syndrome with diarrhea A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint. DOID:676 http://purl.obolibrary.org/obo/DOID_676 juvenile rheumatoid arthritis Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids. DOID:12895 http://purl.obolibrary.org/obo/DOID_12895 keratoconjunctivitis sicca A kidney cortex disease that is characterized by death of the tissue in the outer part of the kidney that results from blockage of the small arteries that supply blood to the cortex and that causes acute kidney injury. DOID:2973 http://purl.obolibrary.org/obo/DOID_2973 kidney cortex necrosis A urinary system disease that is located in the kidney. DOID:557 http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. DOID:1074 http://purl.obolibrary.org/obo/DOID_1074 kidney failure The transfer of a healthy kidney from a donor to a patient for the purpose of replacing one of the failing kidneys of the patient. NCIT:C15265 http://purl.obolibrary.org/obo/NCIT_C15265 Kidney Transplantation A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal. DOID:0050214 http://purl.obolibrary.org/obo/DOID_0050214 Lambert-Eaton myasthenic syndrome A laryngeal disease that is characterized by inward collapse of flaccid supraglottic structures during inspiration. The most common symptom is noisy breathing (stridor) that is often worse when the infant is on his/her back or crying. DOID:0080833 http://purl.obolibrary.org/obo/DOID_0080833 laryngomalacia A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. DOID:1240 http://purl.obolibrary.org/obo/DOID_1240 leukemia A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. DOID:9201 http://purl.obolibrary.org/obo/DOID_9201 lichen planus A bacterial meningitis that has_material_basis_in Listeria monocytogenes infection. DOID:11572 http://purl.obolibrary.org/obo/DOID_11572 Listeria meningitis A hepatobiliary system cancer that is located_in the liver. DOID:3571 http://purl.obolibrary.org/obo/DOID_3571 liver cancer liver disease DOID:409 http://purl.obolibrary.org/obo/DOID_409 liver disease The transfer of a healthy liver allograft from a donor to a patient. NCIT:C15271 http://purl.obolibrary.org/obo/NCIT_C15271 Liver Transplantation localized scleroderma DOID:8472 http://purl.obolibrary.org/obo/DOID_8472 localized scleroderma A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin. DOID:3910 http://purl.obolibrary.org/obo/DOID_3910 lung adenocarcinoma A respiratory system cancer that is located_in the lung. DOID:1324 http://purl.obolibrary.org/obo/DOID_1324 lung cancer A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. DOID:850 http://purl.obolibrary.org/obo/DOID_850 lung disease The surgical transfer of one or both lungs from one individual to another. NCIT:C15274 http://purl.obolibrary.org/obo/NCIT_C15274 Lung Transplantation An autoimmune disease that is characterized by a constellation of findings that include elevated antibodies to nuclear antigens, antiphospholipids, low complement levels, ulcers, non-scarring alopecia, renal or neurologic damage, and low white blood cell and platelet counts, has_symptom rashes, fatigue, arthritis, hair loss, seizures, and symptoms related to affected organs. (UMLS CUI:C0409974) DOID:8857 http://purl.obolibrary.org/obo/DOID_8857 lupus erythematosus A glomerulonephritis that is characterized by inflammation of the kidneys resulting from systemic lupus erythematosus. DOID:0080162 http://purl.obolibrary.org/obo/DOID_0080162 lupus nephritis A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. DOID:11729 http://purl.obolibrary.org/obo/DOID_11729 Lyme disease A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting. DOID:12155 http://purl.obolibrary.org/obo/DOID_12155 lymphocytic choriomeningitis A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. DOID:0060058 http://purl.obolibrary.org/obo/DOID_0060058 lymphoma A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. DOID:12365 http://purl.obolibrary.org/obo/DOID_12365 malaria A primary or metastatic malignant neoplasm involving the stomach. (UMLS CUI:C0024623) NCIT:C9331 http://purl.obolibrary.org/obo/NCIT_C9331 Malignant Gastric Neoplasm A primary or metastatic malignant neoplasm involving the lung. (UMLS CUI:C0242379) NCIT:C7377 http://purl.obolibrary.org/obo/NCIT_C7377 Malignant Lung Neoplasm A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash. DOID:8622 http://purl.obolibrary.org/obo/DOID_8622 measles A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. DOID:9471 http://purl.obolibrary.org/obo/DOID_9471 meningitis A bacterial meningitis that has_material_basis_in Neisseria meningitidis infection. DOID:0080176 http://purl.obolibrary.org/obo/DOID_0080176 meningococcal meningitis A central nervous system disease that involves encephalitis which occurs along with meningitis. DOID:10554 http://purl.obolibrary.org/obo/DOID_10554 meningoencephalitis mental depression DOID:1596 http://purl.obolibrary.org/obo/DOID_1596 mental depression Middle East respiratory syndrome coronavirus SNOMEDCT:697932005 http://purl.bioontology.org/ontology/SNOMEDCT/697932005 MERS-CoV A combination of medical conditions that when present, increase the risk of heart attack, stroke, and diabetes mellitus. It includes the following medical conditions: increased blood pressure, central obesity, dyslipidemia, impaired glucose tolerance, and insulin resistance. NCIT:C84442 http://purl.obolibrary.org/obo/NCIT_C84442 Metabolic Syndrome A food allergy that results in adverse immune reaction to one or more of the proteins in cow's milk and/or the milk of other animals, which are normally harmless to the non-allergic individual. DOID:4376 http://purl.obolibrary.org/obo/DOID_4376 milk allergy Miscarriage is a reproductive system symptom characterized by the spontaneous expulsion of a human fetus before it is viable and especially between the 12th and 28th weeks of gestation. SYMP:0000198 http://purl.obolibrary.org/obo/SYMP_0000198 miscarriage (UMLS CUI:C0026266) DOID:11502 http://purl.obolibrary.org/obo/DOID_11502 mitral valve insufficiency A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen. DOID:3492 http://purl.obolibrary.org/obo/DOID_3492 mixed connective tissue disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center. DOID:8867 http://purl.obolibrary.org/obo/DOID_8867 molluscum contagiosum A myeloid neoplasm that is located_in the plasma cells in bone marrow. (UMLS CUI:C0026764) DOID:9538 http://purl.obolibrary.org/obo/DOID_9538 multiple myeloma Multiple, small, round or oval, benign or malignant growths in the lung(s), which can be due to infectious, inflammatory, or neoplastic processes. (UMLS CUI:C0748164) NCIT:C122408 http://purl.obolibrary.org/obo/NCIT_C122408 Multiple Pulmonary Nodules A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. DOID:2377 http://purl.obolibrary.org/obo/DOID_2377 multiple sclerosis A viral infectious disease that results in inflammation located in salivary gland, has_material_basis_in Mumps rubulavirus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. The infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face. DOID:10264 http://purl.obolibrary.org/obo/DOID_10264 mumps Muscle invasive bladder cancer (MIBC) is a cancer that spreads into the detrusor muscle of the bladder. The detrusor muscle is the thick muscle deep in the bladder wall. This cancer is more likely to spread to other parts of the body. About 1 out of 4 people who get bladder cancer in the United States have the muscle invasive kind. N/A https://www.urologyhealth.org/urologic-conditions/muscle-invasive-bladder-cancer muscle invasive bladder cancer A myopathy is characterized by progressive skeletal muscle weakness degeneration. DOID:9884 http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A disease of anatomical entity that occurs in the muscular and/or skeletal system. DOID:17 http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath. DOID:437 http://purl.obolibrary.org/obo/DOID_437 myasthenia gravis A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia. DOID:5844 http://purl.obolibrary.org/obo/DOID_5844 myocardial infarction An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle. DOID:820 http://purl.obolibrary.org/obo/DOID_820 myocarditis A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work. DOID:8986 http://purl.obolibrary.org/obo/DOID_8986 narcolepsy A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates. DOID:9577 http://purl.obolibrary.org/obo/DOID_9577 neonatal candidiasis Injury to the central nervous system in the newborn period that occurs when there is insufficient delivery of oxygen to all or part of the brain. NCIT:C119751 http://purl.obolibrary.org/obo/NCIT_C119751 Neonatal Hypoxic Ischemic Encephalopathy A disposition inhering in a tumour by virtue of the bearer's disposition to spread and invade distant tissues. PATO:0002098 http://purl.obolibrary.org/obo/PATO_0002098 neoplastic, metastatic A kidney disease characterized by the formation of stoney concentrations in the kidneys. DOID:585 http://purl.obolibrary.org/obo/DOID_585 nephrolithiasis Nephrostomy tube (physical object) (UMLS CUI:C0184149) SNOMEDCT:286628000 http://purl.bioontology.org/ontology/SNOMEDCT/286628000 Nephrostomy tube (physical object) A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability. DOID:1184 http://purl.obolibrary.org/obo/DOID_1184 nephrotic syndrome A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system. DOID:863 http://purl.obolibrary.org/obo/DOID_863 nervous system disease A neurofibromatosis classically characterized by cafe-au-lait spots, Lisch nodules in the eye, and fibromatous tumors of the skin or in some cases by a high load of spinal tumors that has_material_basis_in heterozygous mutation in NF1 on 17q11.2. DOID:0111253 http://purl.obolibrary.org/obo/DOID_0111253 neurofibromatosis 1 A neuropathy that affect the nerves that control the voluntary muscles. (UMLS CUI:C0027868) DOID:440 http://purl.obolibrary.org/obo/DOID_440 neuromuscular disease A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis). DOID:8869 http://purl.obolibrary.org/obo/DOID_8869 neuromyelitis optica A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds. DOID:2929 http://purl.obolibrary.org/obo/DOID_2929 Newcastle disease http://purl.obolibrary.org/obo/DOID_0081014;https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1 DOID:0081014 non-severe COVID-19 Determination of a value is not relevant in the current context NCIT_C48660 http://purl.obolibrary.org/obo/NCIT_C48660 Not Applicable Not stated explicitly or in detail NCIT_C38046 http://purl.obolibrary.org/obo/NCIT_C38046 Not Specified A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. DOID:5113 http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. DOID:9970 http://purl.obolibrary.org/obo/DOID_9970 obesity optic nerve glioma DOID:4992 http://purl.obolibrary.org/obo/DOID_4992 optic nerve glioma An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision. DOID:1210 http://purl.obolibrary.org/obo/DOID_1210 optic neuritis An arthritis that has_material_basis_in worn out cartilage located_in joint. DOID:8398 http://purl.obolibrary.org/obo/DOID_8398 osteoarthritis The surgical transfer of a pancreas from one individual to another. NCIT:C15293 http://purl.obolibrary.org/obo/NCIT_C15293 Pancreas Transplantation An endocrine gland cancer located_in the pancreas. (UMLS CUI:C0235974) DOID:1793 http://purl.obolibrary.org/obo/DOID_1793 pancreatic cancer The surgical transfer of pancreatic islet cells from one individual to another. NCIT:C15352 http://purl.obolibrary.org/obo/NCIT_C15352 Pancreatic Islet Transplantation A skin disease that is characterized by inflammation of subcutaneous adipose tissue. DOID:1526 http://purl.obolibrary.org/obo/DOID_1526 panniculitis paraplegia DOID:607 http://purl.obolibrary.org/obo/DOID_607 paraplegia A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. DOID:14330 http://purl.obolibrary.org/obo/DOID_14330 Parkinson's disease Surgical removal of part of the small intestine. (UMLS CUI:C0192616) NCIT:C51512 http://purl.obolibrary.org/obo/NCIT_C51512 Partial Small Intestine Resection A legume allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms. DOID:4378 http://purl.obolibrary.org/obo/DOID_4378 peanut allergy PANS pediatric acute-onset neuropsychiatric syndrome C000631768 http://purl.bioontology.org/ontology/MESH/C000631768 Pediatric acute-onset neuropsychiatric syndrome A pemphigus characterized by autosomal dominant blisters and erosions on the skin and mucous membranes erosions cause by autoantibodies to intercellular cement substance. DOID:0060851 http://purl.obolibrary.org/obo/DOID_0060851 pemphigus vulgaris peptic ulcer disease DOID:750 http://purl.obolibrary.org/obo/DOID_750 peptic ulcer disease Allergic rhinitis caused by indoor allergens and lasting year round. NCIT:C92189 http://purl.obolibrary.org/obo/NCIT_C92189 Perennial Allergic Rhinitis perinatal necrotizing enterocolitis DOID:8677 http://purl.obolibrary.org/obo/DOID_8677 perinatal necrotizing enterocolitis A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain. DOID:341 http://purl.obolibrary.org/obo/DOID_341 peripheral vascular disease A form of dialysis that uses the peritoneum as a membrane across which the infused diasylate exchanges nutrients for waste products that are removed when the fluid is exchanged. (UMLS CUI:C0031139) NCIT:C15297 http://purl.obolibrary.org/obo/NCIT_C15297 Peritoneal Dialysis A nutritional deficiency disease that is characterized by a decrease in red blood cells due to malabsorption of vitamin B12, has_symptom fatigue, pallor, shortness of breath, glossitis, ataxia, and/or paresthesia, has_material_basis_in atrophic gastritis, autoimmune disorder affecting the production or function of intrinsic factor, and/or genetic factors. DOID:13381 http://purl.obolibrary.org/obo/DOID_13381 pernicious anemia A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop). DOID:1116 http://purl.obolibrary.org/obo/DOID_1116 pertussis A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors. DOID:0060040 http://purl.obolibrary.org/obo/DOID_0060040 pervasive developmental disorder An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as sore throat. The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever. DOID:2275 http://purl.obolibrary.org/obo/DOID_2275 pharyngitis Action in which a part of the body or whole body is involved in movement. XCO_0000059 http://purl.obolibrary.org/obo/XCO_0000059 physical activity A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment. DOID:0080015 http://purl.obolibrary.org/obo/DOID_0080015 physical disorder An endocrine system disease that is located_in the pituitary gland. DOID:53 http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease A uterine disease that is located_in the placenta. DOID:780 http://purl.obolibrary.org/obo/DOID_780 placenta disease A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food. DOID:3482 http://purl.obolibrary.org/obo/DOID_3482 plague A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever. DOID:14067 http://purl.obolibrary.org/obo/DOID_14067 Plasmodium falciparum malaria A malaria that is caused by the protozoan parasite Plasmodium vivax, which induces paroxysms at 48-hour intervals. DOID:12978 http://purl.obolibrary.org/obo/DOID_12978 Plasmodium vivax malaria Pleural effusions, chronic (UMLS CUI:C0747636) UMLS CUI:C0747636 Pleural effusions, chronic A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). DOID:552 http://purl.obolibrary.org/obo/DOID_552 pneumonia A collagen disease that is characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck. DOID:853 http://purl.obolibrary.org/obo/DOID_853 polymyalgia rheumatica A myositis that is characterized by muscle weakness affecting both sides of your body. DOID:0080745 http://purl.obolibrary.org/obo/DOID_0080745 polymyositis A hepatic vascular disease that is characterized by a blood clot that forms within the hepatic portal vein. (UMLS CUI:C0155773) DOID:11695 http://purl.obolibrary.org/obo/DOID_11695 portal vein thrombosis Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. NCIT:C4727 http://purl.obolibrary.org/obo/NCIT_C4727 Post-Transplant Lymphoproliferative Disorder An anxiety disorder which results from a traumatic experience that results in psychological trauma. DOID:2055 http://purl.obolibrary.org/obo/DOID_2055 post-traumatic stress disorder An encephalitis that is characterized by the immune system mistakenly attacking healthy cells in the brain instead of attacking only the cells causing the infection, often occuring two to three weeks after the initial infection. DOID:10993 http://purl.obolibrary.org/obo/DOID_10993 postinfectious encephalitis A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. DOID:10591 http://purl.obolibrary.org/obo/DOID_10591 pre-eclampsia The state or condition of having a developing embryo or fetus in the body (uterus), after union of an ovum and spermatozoon, during the period from conception to birth. NCIT:C25742 http://purl.obolibrary.org/obo/NCIT_C25742 Pregnancy Prenatal maternal abnormality HP:0002686 http://purl.obolibrary.org/obo/HP_0002686 Prenatal maternal abnormality Birth when a fetus is less than 37 weeks and 0 days gestational age. NCIT:C92861 http://purl.obolibrary.org/obo/NCIT_C92861 Preterm Birth Occurring prior to something else. NCIT:C25627 http://purl.obolibrary.org/obo/NCIT_C25627 Previous A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. DOID:12236 http://purl.obolibrary.org/obo/DOID_12236 primary biliary cholangitis An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation. DOID:612 http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease A sclerosing cholangitis characterized by fibroobliterative inflammation of the biliary tract, leading to cirrhosis and portal hypertension. DOID:0060643 http://purl.obolibrary.org/obo/DOID_0060643 primary sclerosing cholangitis Sjogren syndrome without a concomitant systemic autoimmune disorder. NCIT:C116985 http://purl.obolibrary.org/obo/NCIT_C116985 Primary Sjogren Syndrome A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding. DOID:3127 http://purl.obolibrary.org/obo/DOID_3127 proctitis A skin disease that is characterized by patches of thick red skin and silvery scales. DOID:8893 http://purl.obolibrary.org/obo/DOID_8893 psoriasis An arthritis that is characterized by joint inflammation that usually occurs in combination with psoriasis. DOID:9008 http://purl.obolibrary.org/obo/DOID_9008 psoriatic arthritis A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. (UMLS CUI:C1658764) NCIT:C2893 http://purl.obolibrary.org/obo/NCIT_C2893 Psychiatric Disorder A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. DOID:2468 http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. DOID:6432 http://purl.obolibrary.org/obo/DOID_6432 pulmonary hypertension pustulosis of palm and sole DOID:4398 http://purl.obolibrary.org/obo/DOID_4398 pustulosis of palm and sole http://purl.obolibrary.org/obo/NCIT_C61398 NCIT:C61398 Radiation Exposure The complex of symptoms characterizing the disease known as radiation injury, resulting from excessive exposure (greater than 200 rads or 2 gray) of the whole body (or large part) to ionizing radiation. The earliest of these symptoms are nausea, fatigue, vomiting, and diarrhea, which may be followed by epilation, hemorrhage, inflammation of the mouth and throat, and general loss of energy. In severe cases, where the radiation exposure has been approximately 1000 Rad (10 gray) or more, death may occur within two to four weeks. Those who survive six weeks after the receipt of a single large dose of radiation to the whole body may generally be expected to recover. (U.S. Nuclear Regulatory Commission). NCIT:C50723 http://purl.obolibrary.org/obo/NCIT_C50723 Radiation Sickness Syndrome Raynaud disease DOID:10300 http://purl.obolibrary.org/obo/DOID_10300 Raynaud disease A quality of a process which occurs near to or not long before the present. PATO:0001484 http://purl.obolibrary.org/obo/PATO_0001484 recent A medical condition characterized by the loss of two or more pregnancies before the fetus reaches viability. The exact timing for what constitutes "viability" may vary, but losses are often counted before 20 weeks of gestation. Recurrent pregnancy loss is a subset of miscarriage, which is more broadly defined as the loss of a pregnancy before viability. C2921106 https://uts.nlm.nih.gov/uts/umls/concept/C2921106 Recurrent pregnancy loss Repeated infections of the urinary tract. (UMLS CUI:C0262655) HP:0000010 http://purl.obolibrary.org/obo/HP_0000010 Recurrent urinary tract infections A disease stage which is preceded by a remission and characterized by the return of a manifestation of a disease. OGMS:0000105 http://purl.obolibrary.org/obo/OGMS_0000105 relapse A chondromalacia that is characterized by recurrent inflammation of cartilage and other tissues throughout the body. DOID:2556 http://purl.obolibrary.org/obo/DOID_2556 relapsing polychondritis renal artery obstruction DOID:2972 http://purl.obolibrary.org/obo/DOID_2972 renal artery obstruction A surgical procedure in the field of reproductive medicine. NCIT:C157970 http://purl.obolibrary.org/obo/NCIT_C157970 Reproductive Surgery A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress. DOID:1273 http://purl.obolibrary.org/obo/DOID_1273 respiratory syncytial virus infectious disease A musculoskeletal system disease that involves inflammation or pain in the muscles, joints, or fibrous tissue. DOID_1575 http://purl.obolibrary.org/obo/DOID_1575 Rheumatic Disease A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords. DOID:0050827 http://purl.obolibrary.org/obo/DOID_0050827 rheumatic heart disease An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. DOID:7148 http://purl.obolibrary.org/obo/DOID_7148 rheumatoid arthritis A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip. DOID:4483 http://purl.obolibrary.org/obo/DOID_4483 rhinitis An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well. NCIT:C122572 http://purl.obolibrary.org/obo/NCIT_C122572 Rhinovirus Infection A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis. DOID:8781 http://purl.obolibrary.org/obo/DOID_8781 rubella A primary bacterial infectious disease caused by the bacteria of the genus Salmonella. It has sypmtoms diarrhea, fever, vomiting, and abdominal cramps 12 to 72 hours after infection. In most cases, the illness lasts four to seven days, and most people recover without treatment. DOID:0060859 http://purl.obolibrary.org/obo/DOID_0060859 salmonellosis A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs. DOID:11335 http://purl.obolibrary.org/obo/DOID_11335 sarcoidosis A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. DOID:1115 http://purl.obolibrary.org/obo/DOID_1115 sarcoma severe acute respiratory syndrome DOID:2945 http://purl.obolibrary.org/obo/DOID_2945 SARS-CoV SARS-CoV-2 DOID:0080600 https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=2697049 SARS-CoV-2 A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria. DOID:1395 http://purl.obolibrary.org/obo/DOID_1395 schistosomiasis A rheumatic disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs. DOID:419 http://purl.obolibrary.org/obo/DOID_419 scleroderma Allergic rhinitis caused by outdoor allergens. NCIT:C92188 http://purl.obolibrary.org/obo/NCIT_C92188 Seasonal Allergic Rhinitis http://purl.obolibrary.org/obo/DOID_0081013;https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2021-1 DOID:0081013 severe COVID-19 A disorder acquired through sexual contact. NCIT:C3365 http://purl.obolibrary.org/obo/NCIT_C3365 Sexually Transmitted Disorder http://purl.obolibrary.org/obo/NCIT_C157978 C157978 Shigellosis A dislocation of the shoulder joint. (UMLS CUI:C0037005) NCIT:C35020 http://purl.obolibrary.org/obo/NCIT_C35020 Shoulder Dislocation A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape. https://en.wikipedia.org/wiki/Sickle_cell_disease, https://ghr.nlm.nih.gov/condition/sickle-cell-disease, https://www.nhlbi.nih.gov/health-topics/sickle-cell-disease DOID:10923 https://www.disease-ontology.org/?id=DOID:10923 sickle cell anemia A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip. DOID:0050127 http://purl.obolibrary.org/obo/DOID_0050127 sinusitis An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva. DOID:12894 http://purl.obolibrary.org/obo/DOID_12894 Sjogren's syndrome Replacing diseased bowel with healthy bowel tissue. NCIT:C157985 http://purl.obolibrary.org/obo/NCIT_C157985 Small Bowel Transplantation Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age (UMLS CUI: C0235991). NCIT:C114934 http://purl.obolibrary.org/obo/NCIT_C114934 Small for Gestational Age A viral infectious disease that results in infection located in skin, has_material_basis_in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk. DOID:8736 http://purl.obolibrary.org/obo/DOID_8736 smallpox A benign or malignant neoplasm arising from tissues that do not include fluid areas. Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. NCIT:C9292 http://purl.obolibrary.org/obo/NCIT_C9292 Solid Neoplasm An individual who is receiving a transplant of a solid organ. NCIT:C130200 http://purl.obolibrary.org/obo/NCIT_C130200 Solid Organ Transplant Recipient A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination. DOID:0060038 http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy. DOID:12377 http://purl.obolibrary.org/obo/DOID_12377 spinal muscular atrophy Spontaneous abortion is a abortion characterized by the naturally occurring expulsion of a nonviable fetus. SYMP:0000199 http://purl.obolibrary.org/obo/SYMP_0000199 spontaneous abortion Preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes. NCIT:C112864 http://purl.obolibrary.org/obo/NCIT_C112864 Spontaneous Preterm Birth An infectious process in which the bacteria Staphylococcus aureus is present. NCIT:C122576 http://purl.obolibrary.org/obo/NCIT_C122576 Staphylococcus Aureus Infection A skin disease that is characterized by ulceration of less than 10 percent of the surface area of the body. The disease is often precipitated by the use of medications, such as antibiotics or antiepileptics, or onset of infection. DOID:0050426 http://purl.obolibrary.org/obo/DOID_0050426 Stevens-Johnson syndrome Stillbirth is a reproductive system symptom characterized by the birth of a dead fetus, occurs when a fetus which has died in the uterus or during labor or delivery exits a woman's body. SYMP:0000849 http://purl.obolibrary.org/obo/SYMP_0000849 stillbirth Inflammation of the throat due to Streptococcus pyogenes. NCIT:C116003 http://purl.obolibrary.org/obo/NCIT_C116003 Streptococcal Pharyngitis A bacterial pneumonia has_material_basis_in Streptococcus pneumoniae. DOID:0040084 http://purl.obolibrary.org/obo/DOID_0040084 Streptococcus pneumonia A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. DOID:302 http://purl.obolibrary.org/obo/DOID_302 substance abuse A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. (UMLS CUI:C0038586) DOID:303 http://purl.obolibrary.org/obo/DOID_303 substance-related disorder A skin disease that is characterized by sudden onset of well defined tender plaques or nodules accompanied by fever, arthralgias, ocular inflammation, headaches and, rarely, oral or genital lesions. DOID:0080746 http://purl.obolibrary.org/obo/DOID_0080746 Sweet syndrome An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea. DOID:0050211 http://purl.obolibrary.org/obo/DOID_0050211 swine influenza A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. DOID:9074 http://purl.obolibrary.org/obo/DOID_9074 systemic lupus erythematosus A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies. DOID:418 http://purl.obolibrary.org/obo/DOID_418 systemic scleroderma A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli. DOID:11338 http://purl.obolibrary.org/obo/DOID_11338 tetanus An upper respiratory tract disease which is characterized by inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat, painful or difficult swallowing, coughing, headache, myalgia, fever and chills. DOID:10456 http://purl.obolibrary.org/obo/DOID_10456 tonsillitis A syndrome that is characterized by congenital infection with toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and other organisms. DOID:0080835 http://purl.obolibrary.org/obo/DOID_0080835 TORCH syndrome A myelitis that is characterized by a band-like sensation across the trunk of the body, with sensory changes below. DOID:0080743 http://purl.obolibrary.org/obo/DOID_0080743 transverse myelitis A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes. DOID:399 http://purl.obolibrary.org/obo/DOID_399 tuberculosis A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues. DOID:2123 http://purl.obolibrary.org/obo/DOID_2123 tularemia A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production. DOID:9744 http://purl.obolibrary.org/obo/DOID_9744 type 1 diabetes mellitus A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. DOID:9352 http://purl.obolibrary.org/obo/DOID_9352 type 2 diabetes mellitus A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia. DOID:13258 http://purl.obolibrary.org/obo/DOID_13258 typhoid fever A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores. DOID:8577 http://purl.obolibrary.org/obo/DOID_8577 ulcerative colitis A respiratory system disease which involves the upper respiratory tract. DOID:974 http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease Urinary tract obstruction is a blockage that inhibits the flow of urine through its normal path (the urinary tract), including the kidneys, ureters, bladder, and urethra. Blockage can be complete or partial. Blockage can lead to kidney damage, kidney stones, and infection. DOID:5200 http://purl.obolibrary.org/obo/DOID_5200 urinary tract obstruction An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. DOID:13141 http://purl.obolibrary.org/obo/DOID_13141 uveitis A vascular disease that is characterized by inflammation of the blood vessels. DOID:865 http://purl.obolibrary.org/obo/DOID_865 vasculitis A respiratory tract infection caused by a virus. Viruses represent the most common causes of upper and lower respiratory tract infections and include rhinoviruses, influenza viruses, parainfluenza viruses, and respiratory syncytial virus. NCIT:C27219 http://purl.obolibrary.org/obo/NCIT_C27219 Viral Respiratory Tract Infection The specificity of a virus for a particular host tissue, determined in part by the interaction of viral surface structures with receptors present on the surface of the host cell. NA https://www.dictionary.com/browse/viral-tropism viral tropism An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes. DOID:12306 http://purl.obolibrary.org/obo/DOID_12306 vitiligo Water-Electrolyte Imbalance OMIT:0015710 http://purl.obolibrary.org/obo/OMIT_0015710 Water-Electrolyte Imbalance weight loss SYMP:0000178 http://purl.obolibrary.org/obo/SYMP_0000178 weight loss A viral infectious disease that results in inflammation located in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis. DOID:2365 http://purl.obolibrary.org/obo/DOID_2365 West Nile encephalitis A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting. DOID:2366 http://purl.obolibrary.org/obo/DOID_2366 West Nile fever A viral infectious disease that results in infection, has_material_basis_in Yellow fever virus, which is transmitted by Aedes, transmitted by Haemagogus, or transmitted by Sabethes species of mosquitoes. The infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood. DOID:9682 http://purl.obolibrary.org/obo/DOID_9682 yellow fever A viral infectious disease that has_material_basis in Zika virus, which is transmitted_by Aedes aegypti mosquitoes and targets neural progenitor cells and neuronal cells in all stages of maturity and has_symptom fever, has_symptom rash, has_symptom headaches and has_symptom joint pain. DOID:0060478 http://purl.obolibrary.org/obo/DOID_0060478 Zika fever